- Product Details
Keywords
- MM-401(MM 401;MM401)
- 1442106-10-6
- 1442106-10-6
Quick Details
- ProName: MM-401(MM 401;MM401)
- CasNo: 1442106-10-6
- Molecular Formula: C29H46N8O5
- Application: Scientific research
- ProductionCapacity: Metric Ton/Day
- Purity: 98
- LimitNum: 5 Milligram
Superiority
MM-401 (MM 401;MM401) is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM; represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM); specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion; reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.
Details
MM-401 (MM 401;MM401) is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM; represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM); specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion; reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.